IL1B and obesity due to melanocortin 4 receptor deficiency: However, several are useful biomarkers of systemic dysfunction when unchecked inflammation does not resolve, including angiogenin, IL-1β, IL-6, IL-17, osteopontin, osteoprotegerin, RANTES, TNF-α and TGF-β, linking persistent inflammatory mechanisms to arthritis, type 2 diabetes, obesity and cancer (82–85).