Accordingly, our in silico analysis shows Malat1 is involved in a number of pathways involved in DM and its complications that, besides PI3K/Akt, MAPK, and Wnt, include apoptosis, insulin, cell cycle, AMPK, FoxO, ErbB, HIF-1, AGE/RAGE, adipocytokines, and protein processing in endoplasmic reticulum. The gene discussed is INS; the disease is diabetes mellitus.