Consequently, changes in LETM1 expression and function are associated with pathophysiologies, such as insulin resistance in obesity, tumorigenesis, and seizures (Hasegawa and van der Bliek, 2007; Dimmer et al., 2008; Tamai et al., 2008; Jiang et al., 2013; Hart et al., 2014; Park et al., 2014; Li et al., 2019). The gene discussed is LETM1; the disease is obesity due to melanocortin 4 receptor deficiency.