Multiple human malignancies, including breast, colon, esophagus, lung, ovary, rectum, stomach, and uterine cervix, report high LETM1-expression profile correlating with poor prognosis, low survival rates, upregulation of cancer stemness genes, and enhanced angiogenesis (Piao et al., 2009a, 2019a,b, 2020; Li et al., 2015, 2020; Wang et al., 2015, 2020; Huang et al., 2017a; Yang et al., 2018). This evidence concerns the gene LETM1 and cancer.