The change of expression of sortilin and BDNF in our study may be related to dysregulation of glucose homeostasis as hyperglycemia is related to oxidative stress, insulin resistance, and disturbances in acetylcholine homeostasis and the signaling pathway, which involves sortilin, Trk receptors, and BDNF (Morsi et al., 2019). Here, BDNF is linked to Insulin resistance.