FOXP3 and hypertensive disorder: In our study, although there were no differences in the number of Tregs with hypertension in the sexes, females on a HFD with moderate increase in blood pressure vs. age-matched HFD males had increased expression of Foxp3 on Tregs, consistent with females maintaining more Tregs vs. males in Ang II hypertension and SHR (Pollow et al., 2014; Tipton and Sullivan, 2014).