ZINC pre-treatment seems to have protected the cardiac membranes, as evidenced by normalization of ST-segment, but failed to influence the high levels of circulating markers of injury, namely CK-MB and troponin I. Previous studies have shown that zinc treatment protects against ISO-induced MI due to a stabilizing effect on lysosomal membranes (Chvapil et al., 1972), better membrane integrity related to ATPase and phospholipase A2 inhibition (Chvapil and Owen, 1977), and probably by reducing free radical-induced membrane changes (Singal et al., 1981). Here, DNAH8 is linked to myocardial infarction.