This mechanism, by induction of cell motility, could be important for junctional epithelium healing in homeostasis, however, in disbiosis and presence of highly pathogenic microbes when Gal-3 could be overexpressed (Tamai and Kiyoura, 2014), Gal-3 could have opposite role and to contribute to tissue damage, due to the increased expression of MMP-9, proteinase with known role in periodontitis development (Checchi et al., 2020). Here, LGALS3 is linked to periodontitis.