LGALS3 and primary biliary cholangitis: However, in PBC model induced by strong stimulation of immune system with antigen and adjuvant (Arsenijevic et al., 2016), experimental autoimmune encephalomyelitis induced by immunization with MOG35–55 peptide (Jiang et al., 2009), multiple low dose streptozotocin-induced diabetes in mice (Mensah-Brown et al., 2009), acute kidney injury induced by cisplatin (Volarevic et al., 2019), and murine cytomegalovirus induced hepatitis (Stojanovic et al., 2019) Gal-3 plays the protective role, attenuates Th1 and Th17 immune responses and tissue damage.