Blockade of IL-12 is also associated with attenuation of Th1 immune response and Th1 mediated pathology (Malfait et al., 1998), thus Gal-3 mediated capture of IL-12 could attenuate periodontitis since the role of Th1 cells in initiation of periodontal diseases development is known (Gemmell and Seymour, 2004). Here, LGALS3 is linked to periodontitis.