On the other side Gal-3 induces neutrophils infiltration, release of inflammatory cytokines, vascular injury, and release of inflammatory mediators from neutrophils in the mice with lethal infection by Franciscella novicida enhancing thus lung tissue damage and mortality in comparison with Gal-3 deficient mice, despite similar bacterial burden (Mishra et al., 2013). Here, LGALS3 is linked to infection.