Gal-3 deficiency has been found to be associated with inadequate host response to pneumococcal infection, resulting in high mortality of the infected Gal-3 knockout mice (Farnworth et al., 2008; Nieminen et al., 2008; Wright et al., 2017), while exogenous Gal-3 enhances phagocytosis of Streptococcus pneumoniae by both WT and Gal-3 deficient neutrophils (Nieminen et al., 2005; Farnworth et al., 2008). The gene discussed is LGALS3; the disease is pneumococcal infection.