However, deficiency of Gal-3 in advanced stages of periodontitis could lead to enhanced alveolar bone destruction mediated by Th17 cells (Dutzan and Abusleme, 2019) and thus have completely opposite effects in comparison with Gal-3 deficiency in conditions of homeostasis or initial disbiosis of oral micriobiom. Here, LGALS3 is linked to periodontitis.