In murine model of pneumonia it has been shown that Gal-3 accumulates in the alveoli after infection with Streptococcus pneumoniae and this accumulation of Gal-3 is in correlation with the onset of neutrophil extravasation, suggesting the role of Gal-3 in neutrophil activation (Sato et al., 2002). The gene discussed is LGALS3; the disease is pneumonia.