Recent study has been shown that Gal-3, secreted by tumors, binds directly to glycosylated parts of IFN-γ and IL-12, inducing thus their retaining in the extracellular matrix (Gordon-Alonso et al., 2017) avoiding thus IFN-γ diffusion and the formation of an IFNγ-induced chemokine gradient required for CD8+ T cell tumor infiltration. Here, LGALS3 is linked to neoplasm.