APOE and Alzheimer disease: In BV2 cells, MG (10 μM) attenuated Aβ-induced AD by inhibiting the luciferase activity of NF-κB and the target gene of inflammatory cytokines, activating luciferase and liver X receptor activity, reducing ROS production induced by Aβ, upregulating apolipoprotein E (ApoE), and promoting microglial phagocytosis and Aβ degradation (Xie et al., 2020).