CASP8 and neoplasm: It suppressed the growth, migration, and invasion of tumor cells and promoted apoptosis as well as autophagy, through acting on caspase-8, caspase-3, and other proteins participated in the p53, MAPK, NF-κB, TLR, PI3K/Akt/mTOR, and Wnt/β-catenin signaling pathways.