In a word, MG and honokiol suppress the proliferation, migration, and invasion of tumor cells and promote apoptosis as well as autophagy by regulating MAPK, NF-κB, HIF-α, PI3K/Akt/ERK/mTOR, and Wnt/β-catenin signaling pathways (Tse et al., 2005; Vavilala et al., 2014; Lin et al., 2016; Lee et al., 2019). This evidence concerns the gene AKT1 and neoplasm.