CASP8 and neoplasm: MG suppressed the growth, migration, and invasion of tumor cells and promoted apoptosis as well as autophagy by acting on caspase-8, caspase-3, and other proteins participated in the p53, MAPK, NF-κB, TLR, HIF-1α/VEGF, PI3K/Akt/ERK/mammalian target of rapamycin (mTOR), and Wnt/β-catenin signaling pathways (Chen et al., 2013; Liu et al., 2013; Li et al., 2015; Shen et al., 2017; Zhang P et al., 2017).