HNF4A and Disorder of lipid metabolism: Regulates the PCSK9-LDLR pathway → Reduces the level of LDLR protein in the liver → Reduces the plasma concentrations of LDL-C, TG, and TC Xiao et al. (2012) Regulates the HNF-4α-miR122 pathway → Reduces gluconeogenesis and lipid metabolism changes in the liver Wei S et al. (2016). Regulates the AMPKα-SREBP pathway → Prevents olanzapine-induced lipid metabolism disorders Li et al. (2016).