TLR4 and hypertensive disorder: BBR (1.25, 2.5, and 5 μmol/L) could inhibit the apoptosis of aortic endothelial cells isolated from SHR, decrease the expression of TLR4, MyD88, NF-κB, IL-6 and TNF-α, and have a certain protective effect on hypertension-induced vascular endothelial injury (Romero et al., 2011; Wang and Ding, 2015).