PRKN and cardiac hypertrophy: Additionally, BBR also improved cardiac dysfunction and myocardial hypertrophy by upregulating putative kinase 1 (PINK1)/cytosolic E3 ubiquitin ligase (Parkin)-mediated mitochondrial autophagy and inhibited cardiomyocyte apoptosis and mitochondrial damage (Abudureyimu et al., 2020).