Intracellular ROS aggregation can activate NLRP3 inflammasomes by stimulating TRPM2 channels (Wang et al., 2020), or activate microglia cells and induce TNF- production (Alawieyah Syed Mortadza et al., 2018), a neuroinflammatory response induced by Aβ that appears to exacerbate AD (Aminzadeh et al., 2018). Here, TRPM2 is linked to Alzheimer disease.