AstraZeneca in collaboration with Oxford University developed ADZ1222 (previously known as ChAdOx1) COVID-19 vaccine candidate, a Chimpanzee adenovirus-based vaccine using codon-optimized SARS-CoV-2 structural S glycoprotein antigen and synthesized with the tissue plasminogen activator leader sequence (TPA) at the 5’ end. This evidence concerns the gene PLAT and COVID-19.