Wild-type Huntingtin has been shown to be associated with the presynaptic cytomatrix (Yao et al., 2014) and mutant Huntingtin can sequester Bassoon, a polyglutamine containing structural protein, and Piccolo away from the cytoskeletal matrix of the active zone (CAZ) in R6/1 mice and human HD brain (Huang et al., 2020). This evidence concerns the gene HTT and Huntington disease.