Furthermore, NG2 appears to play a crucial role in macrophage migration since there was a significant decrease in macrophage abundance in brain tumors and sites of CNS demyelination in myeloid-specific NG2 null mice (mye-NG2-KO mice; De Castro et al., 2005; Cejudo-Martin et al., 2016; Kucharova and Stallcup, 2017). Here, CSPG4 is linked to brain neoplasm.