VEGF, which has previously been implicated in ALS pathophysiology (Oosthuyse et al., 2001; Lambrechts et al., 2003; Azzouz et al., 2004; Storkebaum et al., 2005), has also been shown to counteract the neurotoxicity of ALS-CSF, reversing morphological changes and decreasing aggregation of phosphorylated neurofilaments (Kulshreshtha et al., 2011). This evidence concerns the gene VEGFA and amyotrophic lateral sclerosis.