In total we analyzed ∼900 peptides mapping to 385 RBPs in addition to tau, Aβ, APP and internal standard peptides, and examined their relative abundance across detergent-insoluble fractions of 44 individual dorsolateral prefrontal cortex tissue samples of patients with pathologically confirmed diagnoses of control, AsymAD, AD or PD. This evidence concerns the gene MAPT and Parkinson disease.