However, U1-70K does not co-aggregate with extracellular Aβ plaques in AD brains, yet in neurons mis-localizes from the nucleus to the cytoplasm were it co-aggregates with NFTs (Diner et al., 2014; Hales et al., 2016; Bishof et al., 2018; Hsieh et al., 2019). Here, SNRNP70 is linked to Alzheimer disease.