In total we analyzed ∼900 peptides mapping to 385 RBPs in addition to tau, Aβ, APP and internal standard peptides, and examined their relative abundance across detergent-insoluble fractions of 44 individual dorsolateral prefrontal cortex tissue samples of patients with pathologically confirmed diagnoses of control, AsymAD, AD or PD. The gene discussed is APP; the disease is Alzheimer disease.