ABL1 and Parkinson disease: It becomes activated by DNA damage and cellular stress, and preclinical data indicated that not only was cAbl kinase activated in models of PD, but cAbl-inhibitors are effective in the laboratory at rescuing the neurodegeneration and associated motor issues (Hebron et al., 2013; Imam et al., 2013; Karuppagounder et al., 2014; Mahul-Mellier et al., 2014; Lee et al., 2018).