PDE6B and Leber congenital amaurosis: Genome editing in the mouse retina has also been attempted for Pde6b-associated RP (using electroporation), Cep290-associated LCA (further discussed below), and Gucy2d-associated cone-rod dystrophy (Ruan et al., 2017; McCullough et al., 2019; Vagni et al., 2019).