Differential correlations in ALS were identified in H2BC11, a histone protein, YBX1, a transcription factor implicated in ALS through model and post mortem tissue analysis, identified as an interactor of TDP-43 and stress granule component (Anders et al., 2018; Nijssen et al., 2018; Feneberg et al., 2020; La Cognata et al., 2020), and EEF1A1, a translational elongation factor and, like YBX1, stress granule component and TDP-43 interactor (Kim et al., 2010; Anders et al., 2018). This evidence concerns the gene H2BC11 and amyotrophic lateral sclerosis.