Module 1 proteins with altered correlation in ALS included RNA and DNA binding proteins and proteins involved in transcription and translation: Putative elongation factor 1-alpha 1 (EEF1A1), Histone H2B type 1-N (H2BC11), Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) and Y-box-binding protein 1 (YBX1); the microtubule protein Tubulin beta chain (TUBB); the glycolytic enzymes Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase (LDHA); and Macrophage migration inhibitory factor (MIF). Here, YBX1 is linked to amyotrophic lateral sclerosis.