As determined by ELISA, knockdown of ADAM8 expression attenuated the release of TNF-α and IL-6 by hepatoma cells and stellate cells as well as the release of IL-6 and CX3CL1 by endothelial cells (Figures 7(g)–7(l) and Figures S4G–S4L). This evidence concerns the gene IL6 and hepatocellular carcinoma.