JAK3 and intestinal disorder: Furthermore, since human colonic polyps show sustained expression of the EMT marker N-cadherin [49, 50] and forced expression of N-cadherin in epithelial cells facilitate neoplastic transformation and colonic polyp formation [51], this physiopathological implications indeed indicate that human colonic polyps have significantly reduced Jak3 expression and localization compared with healthy mucosal counterparts and these polyps have a significantly elevated level of the EMT marker N-cadherin [8].