JAK3 and malignant colon neoplasm: Moreover, as the overexpression of Jak3 also results in chronic inflammation-associated dysregulation of epithelial mesenchymal transition, which is the first step of the colon cancer, in future, it is important to decipher the molecular player and environmental factor (e.g., diet and/or gut microbiota) that regulate its expression in gastrointestinal tract (Figure 9).