METTL3 also regulates the Wnt/β-catenin pathway in HB by increasing the m6A level of important genes in the pathway such as CTNNB1 (β-catenin), CCND1 (cyclin D1), NKD1 (NKD inhibitor of Wnt signaling pathway 1) etc. In HB a significant positive correlation has been found between METTL3 and CTNNB1 gene that encodes for β-catenin. This evidence concerns the gene CTNNB1 and hemoglobin measurement.