Knocking down MOR-1 through antisense oligonucleotides or the MOR-1 antagonist naloxone conferred protection of pyramidal neurons to ischemia-induced cell death, potentially by disinhibiting GABA release from inhibitory interneurons, demonstrating MOR-1 to be pathological in this model (Formisano et al. 2007). Here, OPRM1 is linked to ischemia.