BDNF and its receptor TrkB are both upregulated in epilepsy and their repression by REST seems to be an important regulatory switch to protect against epileptogenesis (Isackson et al. 1991; Nibuya et al. 1995; Binder et al. 1999a, 1999b; Dinocourt et al. 2006). Here, NTRK2 is linked to epilepsy.