The cytokine storm in adult COVID-19 is characterised by increased IL-1, IL-6 and TNF-α, [19,20,24] and predominantly involves the respiratory system, whereas the cytokine storm in PIMS-TS, with elevated IFNγ, TNFα, IL-6, IL-10 and IL-17A, [4], [5], [6] involves multiple systems mainly gastrointestinal, mucocutaneous and cardiac, with few or no respiratory manifestations [3,22]. The gene discussed is IFNG; the disease is COVID-19.