Furthermore, we verified that the effect on PARs is mainly due to a chronic state of unbalanced glucose metabolism rather than to acute hyperglycemia, since the expression of PAR-1 and PAR-4 in platelets did not change in a subgroup of healthy controls in comparison to GGC (Additional file 1: Fig. S2a–c). The gene discussed is F2RL3; the disease is Hyperglycemia.