Then, to provide experimental evidence that PARs can differentially influence the release of MPs from platelets, we measured the effects of TRAP-6, a PAR-1 agonist, and of AY-NH2, a PAR-4 agonist, on the production of PMP from platelets of GGC and PGC T2DM. Here, F2RL3 is linked to type 2 diabetes mellitus.