TP53 and psoriasis: However, p53 protein was predicted to be upregulated at 6 h after 311 nm UVB irradiation (Fig. 5A and Supplementary Fig. 4) by IPA and we observed upregulation of p53 nuclear protein at 18 h by 311 nm but not 290 nm UVB in lesional psoriasis skin (Supplementary Fig. 5).