In DN with macroalbuminuria group, there were positive correlations between serum CN-1 and expressions of FN (r = 0.822, p = 0.000), Col-IV (r = 0.562, p = 0.005) and Col-I (r = 0.516, p = 0.011). The gene discussed is CNDP1; the disease is liver dysplastic nodule.