We further noted that ACTH gradients were higher in patients with a histologically confirmed adenoma compared to those without, both before (19.2±8.7 vs. 6.6 ± 2.6; p=0.12) and after (74.8± 43 vs. 9.6 ± 5.5, p=0.08) oCRH stimulation, but not significantly. This evidence concerns the gene POMC and adenoma.