High ACTH and corticosterone levels following HPA activity induced a loss of volume (Rahman et al., 2016), synaptic degeneration, neuronal atrophy (Popoli et al., 2012), decline in the number of dendrites, loss of dendritic spines, and deficits in neurogenesis (Conrad, 2008) in the hippocampus that resulted in spatial learning and memory impairments. Here, POMC is linked to memory impairment.