EZH2 and Ewing sarcoma: Our new finding that EZH2 is not a major regulator of GD2 expression in OS was not unexpected: Whereas Ewing sarcoma is driven by a disease‐defining translocation, with consistent high‐level EZH2 expression as a direct consequence of the resulting fusion protein,32 OS is characterized by a disorganized genome with highly variable and complex chromosomal alterations.33