For example, knockdown of ADAM9 expression decreased lung cancer metastases to the brain [38], RNA interference to ADAM9 attenuated the invasiveness of Tenascin‐C‐stimulated brain tumor‐initiating cells [39] and ectopic expression of ADAM9 abolished microRNA (miR)‐1272‐induced inhibition of glioma cell migration [40]. This evidence concerns the gene ADAM9 and central nervous system cancer.