We observed significantly more cortical Iba1-positive cells in the ischemic lesions of CKD-veh than those of SHAM-veh mice (CKD-veh: 44.30 ± 6.25 vs. SHAM-veh: 24.53 ± 6.47 Iba1-positive cells/field, p < 0.001) (Fig. 3A). The gene discussed is AIF1; the disease is chronic kidney disease.