Moreover, phosphorylated eIF2α was observed in the absence of PKR during SARS-CoV-2 infection (Fig. 8D) but not SINV (SI Appendix, Fig. S5B), suggesting that other kinases may contribute to phosphorylation of eIF2α during infection with SARS-CoV-2 in particular (Fig. 8D). The gene discussed is EIF2A; the disease is infection.