For LV dysfunction-related decompensated MR, 12 significant DEGs (CTGF, MAP1B, SERPINE1, MYH9, MICAL2, MYO1D, CRY1, AQP7P3, HTRA1, PRSS23, IGFBP2 and FN1) passed the 1% FDR significance threshold. The gene discussed is PRSS23; the disease is miotic rate.