Some alveolar macrophages in the ex vivo cell cultures obtained from the tuberculoma walls of TB patients 28 and 29 demonstrated the COX-2 expression in the areas corresponding to the location of endoplasmic reticulum (Figure 4D),while in other marker-positive cells, COX-2 molecules were defined in intracellular vesicles (Figure 4D). This evidence concerns the gene PTGS2 and tuberculosis.