HIF-1α and HIF-2α stabilization in the TB patients’ cells was virtually unobserved in the “tuberculoma” group and was absent from the “type I” group, while the lung tissue samples in both groups were characterized by an increased level of tissue fibrosis and, probably, alveolar macrophages in such pathologically fibrotic tissues were under hypoxic conditions. This evidence concerns the gene EPAS1 and tuberculosis.