The translocation of SOX9 to a sex chromosome may be problematic for complete organogenesis or chondrogenesis if gene dosage were altered; for example, 50%-reduced gene dosage in mice leads to bone and endocrine-specific defects similar to those observed in human haploinsufficiency syndrome Campomelic Dysplasia patients [121,122,123,124]. The gene discussed is SOX9; the disease is campomelic dysplasia.