VEGFA and glioblastoma: Preliminary results of the Checkmate 143 mentioned above led to the opening of a large randomized open-label phase III study (expansion of cohort 2) directly comparing the efficacy and safety of nivolumab monotherapy versus the anti-vascular endothelial growth factor A (VEGF-A) mAb bevacizumab in GBM patients at first recurrence after standard chemoradiation.