PDAC metastatic behaviour is strongly influenced by stromal cells in the tumour microenvironment and pharmacological inhibition of signaling events initiated by factors released from stroma cells, including hepatocyte growth factor, insulin-like growth factor 1 or tenascin C, reduced AnxA2 phosphorylation and metastatic potential of PDAC tumours [139,140,153]. This evidence concerns the gene ANXA2 and neoplasm.