In earlier studies, annexin anomalities, also called ‘annexinopathies’, were initially reported in two disease states, identifying AnxA2 overexpression in patients with a haemorrhagic form of acute promyelocytic leukaemia, and AnxA5 downregulation on placental trophoblasts in the antiphospholipid syndrome [434,435]. This evidence concerns the gene ANXA5 and antiphospholipid syndrome.