In EGFR overexpressing A431 epithelial carcinoma lacking endogenous AnxA6 [311,312], restoration of AnxA6 expression promoted PKCα-mediated threonine 654-EGFR phosphorylation, which inhibited EGFR tyrosine kinase activity, cell growth, migration and invasion [313,344]. Here, ANXA6 is linked to carcinoma.