In line with these findings, Rab7-GTP levels were elevated in mouse embryo fibroblasts from Anxa6−/− mice [337], indicating that the gatekeeper function of AnxA6 to control cholesterol transport from late endosomes could be relevant in vivo and the progression of NPC disease [338] (Table 6e). This evidence concerns the gene ANXA6 and nasopharyngeal carcinoma.