ANXA1 and peritonitis: Mechanistically, in carrageenan-induced paw oedema and zymosan-induced peritonitis, the prominent ability of AnxA1 to counteract inflammatory events occured through binding of extracellular AnxA1 to formyl peptide receptors (FPRs), a family of G-protein coupled receptors found on many cells of the innate immune system, including neutrophils and monocytes [26,27].