On the other hand, AnxA5 knockdown impeded tumourigenesis in subcutaneous xenografts from renal cell carcinoma [264], with the latter two studies suggesting an involvement of PI3K/Akt signaling and implicating AnxA5 as a potential biomarker in glioma and renal cell carcinoma. The gene discussed is ANXA5; the disease is hereditary clear cell renal cell carcinoma.