Although NF-κB is known to regulate immune and inflammatory responses, it also regulates the expression of cancer cell related genes such as those involved in proliferation (e.g., CCND1), angiogenesis (e.g., VEGF), invasion (e.g., MMP9), metastasis (e.g., ICAM1), and apoptosis (Promoting apoptosis (e.g., FAS) or Inhibiting apoptosis (e.g., BCL2)) [226]. The gene discussed is NFKB1; the disease is cancer.