Additionally, it is relevant that peripheral neuropathy can be caused by pathogenic variants in mitochondrial protein chaperones such as HSPB8 (HSP22) [365], HSPB1(HSP27) [366], and TID1 [367], and that modulating chaperones can improve sensory fiber recovery in diabetic peripheral neuropathy [368]. This evidence concerns the gene HSPB8 and peripheral neuropathy.