We next sought to determine whether the significant changes observed in CB1 and CB2 expression in B-lymphocytes, and of CB2 and FAAH in monocytes, correlated to the neurological and neurocognitive severity of AD patients, assessed through mini-mental state examination (MMSE) scores, where higher MMSE scores are associated with milder dementia. This evidence concerns the gene CNR1 and Alzheimer disease.