Okamoto et al. also reported that paclitaxel-albumin complex-encapsulated liposomes had a potent antitumor effect on 2D-cultured and 3D-cultured triple-negative breast cancer cells (MDA-MB-231 cell), an intractable form of breast cancer that is resistant to conventional hormone and molecular target agent therapy due to the absence of progesterone receptors, estrogen receptors, and the human epidermal growth factor receptor-2 [88]. This evidence concerns the gene ALB and triple-negative breast carcinoma.