ALB and neoplasm: As a result, liposome co-encapsulated paclitaxel-loaded albumin nanoparticles and the ellagic acid-loaded albumin nanoparticles both penetrated deeply into the core of BxPC-3 (human pancreatic cells) and HPaSteC (human pancreatic stellate cells) tumors in xenograft tumor-bearing model mice, indicating that the co-encapsulation of ellagic acid represents a promising strategy for improving penetration into the matrix.