When RHS interreact with extracellular myeloperoxidase (MPO) produced by neutrophils to provide immune system defenses against pathogens, it results in tissue damage, cellular damage, and inflammatory reactions that facilitate the occurrence of a variety of diseases, particularly CVD (atherosclerosis), obesity, T2DM, and, ultimately, metabolic syndrome (MetS) [10,18]. Here, MPO is linked to atherosclerosis.