The clear reduction of myelination in ALS corticospinal tracts and ventral horn gray matter of the spinal cord was obviously consistent with the finding that the newly generated oligodendrocytes were dysfunctional and failed both in terms of myelin synthesis and trophic support as suggested by the lower expression of MBP and MCT1, respectively [89,107]. Here, MBP is linked to amyotrophic lateral sclerosis.