Optineurin is a gene for which loss-of-function mutations have been linked to ALS, not for motor neuron death or paralysis, but for other features namely including lower number of axons, abnormally large caliber axons, and signs of thicker, less compact myelin sheaths in the spinal ventrolateral white matter and to a lesser extent in the anterior roots from the age of three weeks [135]. Here, OPTN is linked to amyotrophic lateral sclerosis.