Besides the detection of TDP-43 cytoplasmic inclusions within oligodendrocytes in the motor cortex and spinal cord of ALS patients [80,87,88,89,90], similar inclusions of this protein normally involved in various aspects of RNA processing and thus present in the cell nucleus have been observed in different animal models of the disease including the mutant SOD1 mice. Here, TARDBP is linked to amyotrophic lateral sclerosis.