However, a specific link between microglia and oligodendrocyte degeneration has been established in ALS via data reporting that the lack of optineurin function in microglia activates an intrinsic cascade that triggers these cells to adopt a RIPK1-dependent pro-inflammatory phenotype (including TNFα secretion) assumed to kill neighboring oligodendrocytes by promoting their necroptosis [93]. The gene discussed is OPTN; the disease is amyotrophic lateral sclerosis.