Finally, although neither directly linked to oligodendrocyte involvement in ALS pathogenesis nor usable as a possible therapeutic perspective, an amazing observation has reported that myelin antigen-mediated immunization of the SOD1G93A mutant allowed choroid plexus activation and the subsequent recruitment of immunoregulatory cells (including IL-10-producing macrophages and Foxp3 regulatory T cells) in the spinal cord, likely responsible for mitigating disease progression and increasing animal survival [170]. The gene discussed is IL10; the disease is amyotrophic lateral sclerosis.