The present study had several limitations which included lack of BMI, laboratory data which reflects nutritional conditions (blood count, total protein, serum albumin, choline esterase, total cholesterol, and so on), comorbidities (presence of cerebrovascular disease, spinal disease, musculoskeletal disorders, and so on), medications, physical and cognitive functions, and voiding/defecation desires evaluated by global indicators. The gene discussed is BCHE; the disease is musculoskeletal system disorder.