Additionally, mTOR inhibitors (sirolimus) have been found to be associated with a higher risk for PTDM as a result of sirolimus-induced hyperglycemia caused by compromised insulin-mediated suppression of hepatic glucose production, the accumulation of ectopic triglycerides and subsequent insulin resistance, as well as direct pancreatic β-cell toxicity [49]. The gene discussed is INS; the disease is Hyperglycemia.