The negative effects of therapy with corticosteroids involve the impairment of insulin secretion, the aggravation of insulin resistance related to higher rates of gluconeogenesis in the liver as well as indirect impact on weight gain, the rise in lipolysis-induced dyslipidemia, and the decrease in muscle mass, glycogen synthesis and glucose uptake in skeletal muscle cells [35,46,49]. This evidence concerns the gene INS and Insulin resistance.