Although studies have suggested that tumor TP53 mutation status is not always a good indicator of prognosis [4,19], our data suggests that incorporating information from certain TP53 transcripts, such as the t2/t1 ratio, in addition to TP53 mutation status of the tumor, may be a more accurate predictor of patient prognosis than clinical and pathological information alone. The gene discussed is TP53; the disease is neoplasm.