This showed that the TP53 mutation status was strongly associated with breast cancer subtype (p = 4.7 × 10−5), tumor ER (p = 1.3 × 10−4) and PgR status (p = 6.5 × 10−6) and histological grade (p = 4.4 × 10−6) (Table S2). This evidence concerns the gene ESR1 and breast cancer.