Sequeiros et al. isolated uEVs from low- and high-grade PCa patients using UC and reported that the ADSV-TGM4 panel accurately classified non-PCa and PCa patients and a panel of five proteins (PSA; CD63 antigen, CD63; putative glycerol kinase 5, GLPK5; N-sulphoglucosamine sulphohydrolase, SPHM; and prostatic acid phosphatase, PAPP) significantly discriminated between high- and low-grade PCa [69]. This evidence concerns the gene TGM4 and posterior cortical atrophy.