The Asian Cancer Research Group (ACRG) also proposed a 4-group classification based on mRNA expression, somatic copy number and targeted gene sequencing: microsatellite instability (MSI), microsatellite stable and epithelial to mesenchymal transition phenotype (MSS/EMT), microsatellite stable and presence of TP53 (MSS/TP53+) or no TP53 signature (MSS/TP53-) [8]. Here, TP53 is linked to cancer.