TP53 and gastric cancer: To overcome this challenge, Setia et al. proposed techniques available in routine diagnostic practice like in situ hybridisation and immunohistochemistry and identified 5 GC groups: EBV-positive (5% cases), mismatch repair-deficient (16%), aberrant E-cadherin expression (21%), aberrant p53 expression (51%) and normal p53 expression (7%) [9].