The bacterial infection up-regulates oncoprotein YAP1 but also its negative regulator LATS2, a Hippo tumour suppressor kinase, in a coordinated biphasic manner, with an early temporary oncogenic YAP1 activation, followed by LATS2 activation leading to YAP1 phosphorylation and downregulation and thus, oncogenic signal restriction [40]. Here, YAP1 is linked to bacterial infectious disease.