Whether TRIM24 and TRIM28 can co-operate in cancer stemness regulation should also be addressed, as in several tumor types (i.e., BRCA, LUSC, or STAD), their expression, as well as their associated transcriptome profiles, are simultaneously correlated or enriched with stem cell markers and both TRIM24 and TRIM28 are direct regulators of core stem cell transcription factors in normal stem cells [10,18]. This evidence concerns the gene TRIM28 and cancer.