In addition, these observations regarding sEHi treatment are in agreement with previous reports that demonstrated that long-term administration of TPPU, a well-characterized sEHi, to the 5xFAD mouse model of AD also rescued SYN and PSD95 levels [46], suggesting that the improvement of synaptic plasticity and cognitive performance in the NPC mice model could be attributed to sEH inhibition. This evidence concerns the gene EPHX2 and Alzheimer disease.